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Tianming Zhao

MRes student

Research experience

I am currently pursuing a Bachelor's degree in Basic Medical Sciences at Zhejiang University, while also working towards an MRes in Oncology at the University of Oxford.

 

During my undergraduate studies, I had the privilege of working in Professor Di Wang’s lab, where our research focused on three key areas: tissue repair, intestinal immunity, and tumor immunity. Under the guidance of Dr. Zhexu Chi, I contributed to a number of exciting projects. Three papers I contributed to align with these three research directions:

  • Tissue repair - Chi Z, Chen S, Yang D, Cui W, Lu Y, Wang Z, Li M, Yu W, Zhang J, Jiang Y, Sun R, Yu Q, Hu T, Lu X, Deng Q, Yang Y, Zhao T, Chang M, Li Y, Zhang X, Shang M, Xiao Q, Ding K, Wang D. Gasdermin D-mediated metabolic crosstalk promotes tissue repair. Nature. 2024 Oct;634(8036):1168-1177. doi: 10.1038/s41586-024-08022-7. Epub 2024 Sep 11. PMID: 39260418.
  • Intestinal immunity - Yu Q, Jiang D, Zhao T, Guan Y, Zhang J, Chi Z, Yang D, Sun R, Yu W, Wang Z, Chen S, Li M, Hu T, Deng Q, Lu X, Yang Y, Chang M, Du L, Zhang X, Wang D. Gasdermin D in the small intestine. Unpublished.
  • Tumor immunity - Lu Y,  Zhao T,  Chi Z,  Wang D. Regulation of immune cell metabolism in tumor microenvironment. Progress in Pharmaceutical Sciences. 2022, 46(8): 577-587. doi: 10.20053/j.issn1001-5094.2022.08.003.

 

One paper provides a comprehensive overview of the role of the star molecular Gasdermin D across these three contexts.

  • Comprehensive overview - Zhao T, Chi Z, Wang D. Gasdermin D: from pyroptosis to cellular versatility. Unpublished.

 

As part of my graduate studies, I am now working in the lab of Associate Professor Eileen Parkes, where we focus on the regulation of the cGAS-STING pathway in tumor microenvironment. My current research is centered around T cells and dendritic cells, exploring their interactions and implications in immune responses.

Research interest