CIO supports a spectrum discovery research from atoms to humans with a focus on improving human health.  Our PI’s have a wide range of immunological expertise and this is reflected in their interdisciplinary groups – where structural biologists and mathematicians, oncologists and infection immunologists, scientists and clinicians come together to focus their efforts in two overarching themes: transformation immunobiology – investigating changes in tissue and systemic  immunity along the (pre-)cancer trajectory and anti-tumour specificity – the study of lymphocyte recognition of cancer antigens. Together, these themes allow us to build a picture of how specific immunity to cancer is initiated and deployed in peripheral tissues, and guide us to developing more effective immunotherapies and immunological interceptions.  Underpinning these themes are two cross-cutting themes: the application of mathematical and computational systems-level approaches, and molecular mechanism.

Research groups are highly interactive and collaborate widely within Oxford and externally around several research areas