We are seeking to appoint a highly motivated Senior Research Scientist in Mass Spectrometry-based Immunopeptidomics with a strong interest in cancer immunology and innovative approaches for antigen discovery in cancer. You will have hands-on experience with mass spectrometry-based proteomics, including instrument operation, maintenance and data analysis workflows. You will contribute to a research programme focused on deciphering the molecular architecture of the HLA antigen processing and editing machinery, and investigating how it shapes tumour-specific antigen presentation. Your project will focus on identifying tumour-specific and immunogenic antigens from primary tumour tissues using advanced immunopeptidomics approaches as part of a multi-team initiative to design and deliver cancer-preventing vaccines jointly led by the University of Oxford and GSK.

 

You will be responsible for LC-MS/MS data acquisition and analysis, development of sensitive workflows for neoantigen discovery and maintenance of instrumentation. The role also involves managing independent research projects, supervising junior researchers, and keeping up to date with latest developments in the fields of immunopeptidomics and cancer vaccine research.

 

The applicant will join the T-cell Epitope Discovery Group led by Dr. Eleni Adamopoulou, within the Centre for Immuno-Oncology directed by Professor Timothy Elliott.

 

It is essential that you hold a PhD/DPhil in Chemistry, Biochemistry, Immunology, Molecular Biology, or a related field, with hands-on experience operating and maintaining Bruker and/or Thermo LC-MS/MS platforms. Proficiency in data acquisition methods  such as DDA, DIA, or PRM, and in data analysis tools such as PEAKS, MSFragger, MaxQuant, Proteome Discoverer, or Skyline is also required. The ability to manage multiple projects effectively along with excellent interpersonal and communication skills and a collaborative mindset, is essential. A working knowledge of immunology or a willingness to learn, experience with quantitative mass spectrometry assays, and computational skills including R or Python are highly desirable.

 

Applications for this vacancy should be made online and you will need to upload a supporting statement and CV. Your supporting statement must explain how you meet each of the selection criteria for the post using examples of your skills and experience. Please restrict your documentation to your CV and supporting statement only. Any other documents will be requested at a later date.

 

This position is offered full time on a fixed term contract until 31 December 2027 and is funded by GSK.

 

Only applications received before 12 midday on 9 June 2025 will be considered. Please quote 179719 on all correspondence.

We have an exciting opportunity for a Research Assistant to join the research group headed by Professor Geraldine Gillespie and Emeritus Professor Andrew McMichael in the Nuffield Department of Medicine, Centre for Immuno-Oncology, which carries out basic and translational immunological research on the non-classical major histocompatibility molecule (MHC), HLA-E.

 

You will be responsible for establishing in vitro co-culture systems of primary CD8+ T cells with 3D cultures of HPV-containing keratinocytes and fibroblasts (e.g., spheroids or organotypic raft cultures) for testing engineered T-cell therapies in pre-clinical proof-of-concept studies. You will perform lab-based experimental work of a high standard, to carry our techniques carefully and accurately and keeping good records of all work performed. This work also includes contributing to presentation of research reports and publications and smooth running of the laboratory ensuring that work in the Department is conducted safely and legally.

 

It is essential that you hold a BSc degree in a relevant biomedical science area together alongside experience with mammalian tissue culture and, ideally, with establishing 3D tissue culture systems (e.g., spheroids or organoids). You will also have experience in growing primary CD8+ T cells and T cell lines. You will also have excellent communication skills and will be able to work independently as well as part of a multidisciplinary team. Having experience of working with murine tissue samples is desirable.

 

Applications for this vacancy should be made online and you will need to upload a supporting statement and CV. Your supporting statement must explain how you meet each of the selection criteria for the post using examples of your skills and experience. Please restrict your documentation to your CV and supporting statement only. Any other documents will be requested at a later date.

 

This position is offered full time on a fixed term contract until 30 November 2026 and is funded by Bill and Melinda Gates Foundation.

 

Only applications received before 12 midday on Wednesday 11 June 2025 will be considered. Please quote 179347 on all correspondence.

We are seeking to appoint a highly motivated Postdoctoral Researcher to join the research group of Professor Ignacio Melero, MD PhD, at the Oxford Centre for Immuno-Oncology within the Nuffield Department of Medicine.

 

The translational immunotherapy lab, led by Professor Melero, focuses on the development, study, and mechanistic understanding of innovative immunotherapeutic strategies for cancer. The research is primarily translational in nature, involving both preclinical models and human sample analysis from clinical trials, and is carried out in close collaboration with the pharmaceutical industry.

 

You will be responsible for managing your own academic research and administrative activities, including coordinating small-scale projects to meet deadlines. You will adapt existing and develop new scientific techniques and experimental protocols, test hypotheses, and analyse data from various sources, refining working hypotheses as needed. You will lead the development of a research project, stay up to date with relevant literature, and maintain accurate experimental records. Regular discussions with lab members, presenting findings at national and international symposia, and contributing to publications will also be key parts of your role. You will supervise and support junior lab members, assist with grant applications, and engage in internal and external collaborative activities such as seminars and conferences. In addition, you will design and analyse mouse model experiments, apply cellular immunology techniques, and conduct preclinical studies involving immunotherapeutic treatments. You will perform RNA-seq, Nanostring analysis, TCR clonality, in vivo killing assays, and monitor clinical trial samples using flow cytometry, ELISAs, ELISPOT, RT-PCR, and chromium release assays.

 

It is essential that you hold a relevant PhD/DPhil in Immunology (or is close to completion), with demonstrated experience in immunology and working with primary human lymphocytes. The role requires the ability to work both independently and collaboratively, as well as evidence of contributing to published immunology research. Strong communication skills are vital, including the ability to write for publication, present research findings, and represent the group at meetings. A working knowledge of bioinformatics is also essential.

 

One or more first-author scientific publications, experience in protein purification and flow cytometry, and additional bioinformatics skills are highly desirable. Experience managing a discrete area of a research project, collaborating on research publications.

 

Applications for this vacancy should be made online and you will need to upload a supporting statement and CV. Your supporting statement must explain how you meet each of the selection criteria for the post using examples of your skills and experience. Please restrict your documentation to your CV and supporting statement only. Any other documents will be requested at a later date.

 

This position is offered full time on a fixed term contract for 2 years and is funded by Michael Stanley Funds.

 

Only applications received before 12 midday on 22 May 2025 will be considered. Please quote 179094 on all correspondence.