The Center for Immuno-Oncology (CIO) investigates how our immune system reacts to cancer and what we can do to improve tumour immunity. We combine deep fundmental understanding of immunology with preclinical studies to translate new knowledge into clinical trials with the aim of developing new life-saving treatments for a spectrum of cancers.
Oxford’s long history of excellence in immunology is now focused on cancer, and CIO is the hub of the University-wide Oxford Cancer Immuno-Oncology Network (OCION) which links immuno-oncology researchers from multiple disciplines from across the University of Oxford, its affiliated hospitals and industrial partners.
What's new for Oxford Cancer
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Platelets shown to store DNA in study that could transform cancer screening
15 August 2025
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Oxford researchers create first atlas showing cell interaction in lung fibrosis
5 August 2025
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Scientists reveal how cells repair toxic DNA damage linked to cancer and premature ageing
4 August 2025
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Oxford Clinical Researcher Awarded NIHR EME Funding to Study Impact of Insulin Levels on Breast Cancer Treatment Response
1 August 2025
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Advance Your Research with the SCAN Pathway
21 July 2025
CIO News
A Day of Science, Creativity, and Connection at the CIO Away Day
6 August 2025
The Centre for Immuno-Oncology came together last week for a vibrant and inspiring CIO Away Day. In the beautiful Rhodes house we enjoyed a full day of science, creativity, reflection, and community.
Professor Andrew McMichael elected to the US National Academy of Sciences
20 May 2025
The National Academy of Sciences (NAS) in the US announced the election of 120 members and 30 international members in recognition of their distinguished and continuing achievements in original research. Election to membership in the NAS is a mark of excellence in science and is considered one of the highest honours that a scientist can receive.
Oxford Immunology Symposium 2025
3 February 2025
The BSI Oxford Immunology Group, in collaboration with the University of Oxford Immunology Network, is pleased to present a one-day showcase of the fantastic immunology research happening across Oxford.
Agonists and Antagonists in Combined Immunotherapies for Cancer
3 February 2025
Prof. Nacho Melero delivers a talk on Immunotherapies in Cancer for GLOBAL IMMUNOTALKS
Latest publications
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Nanotechnology for immuno-oncology.
Journal article
Grippin AJ. et al, (2025), Nature cancer
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T cell engagers: expanding horizons in oncology and beyond.
Journal article
Albayrak G. et al, (2025), Br J Cancer
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Atom-level mechanism of tapasin-independent peptide editing by Major Histocompatibility Complex class I molecules
Preprint
Turner S. et al, (2025)
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Strict advantage of complex quantum theory in a communication task
Journal article
Elliott TJ., (2025), Physical Review A, 111
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Antigen-presenting mast cells are new players in breast cancer immunotherapy.
Journal article
Luri-Rey C. et al, (2025), Nature medicine
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In vivo labelling resolves distinct temporal, spatial, and functional properties of tumour macrophages, and identifies subset-specific effects of PD-L1 blockade.
Journal article
Lee CY. et al, (2025), Cancer immunology research
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Dual ENPP1/ATM depletion blunts DNA damage repair boosting radioimmune efficacy to abrogate triple-negative breast cancer.
Journal article
Ruiz-Fernández de Córdoba B. et al, (2025), Signal transduction and targeted therapy, 10
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Phase II study of perioperative Avelumab plus chemotherapy for patients with resectable gastric cancer or gastroesophageal junction cancer - the MONEO Study.
Journal article
Alsina M. et al, (2025), Clin Cancer Res
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Supplemental Figure 2 from Dynamic Tracking of Tumor Microenvironment Modulation Using Kaede Photoconvertible Transgenic Mice Unveils New Biological Properties of Viral Immunotherapy
Other
Diers AR. et al, (2025)
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Supplementary Figure S1 from Dynamic Tracking of Tumor Microenvironment Modulation Using Kaede Photoconvertible Transgenic Mice Unveils New Biological Properties of Viral Immunotherapy
Other
Diers AR. et al, (2025)
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Supplemental Figure 5 from Dynamic Tracking of Tumor Microenvironment Modulation Using Kaede Photoconvertible Transgenic Mice Unveils New Biological Properties of Viral Immunotherapy
Other
Diers AR. et al, (2025)
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Supplemental Figure 3 from Dynamic Tracking of Tumor Microenvironment Modulation Using Kaede Photoconvertible Transgenic Mice Unveils New Biological Properties of Viral Immunotherapy
Other
Diers AR. et al, (2025)
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Supplemental Figure 4 from Dynamic Tracking of Tumor Microenvironment Modulation Using Kaede Photoconvertible Transgenic Mice Unveils New Biological Properties of Viral Immunotherapy
Other
Diers AR. et al, (2025)
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Chromosomal instability shapes the tumor microenvironment of esophageal adenocarcinoma via a cGAS-chemokine-myeloid axis.
Preprint
Beernaert B. et al, (2025)
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CINs of the cytoplasm: dissecting dsRNA signaling in chromosomal instability.
Journal article
Skolariki A. et al, (2025), Mol Oncol
Oxford Talks
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Tuesday, 19 August 2025, 4pm to 5.30pm
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Wednesday, 20 August 2025, 5pm to 6pm
Speakers: Daniel Porterfield
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Thursday, 21 August 2025, 1pm to 2pm
Speakers: Professor Sebastian Springer
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Wednesday, 27 August 2025, 11.30am to 12.30pm
Speakers: Professor Tulio de Oliveira
Venue: Big Data Institute, Old Road Campus OX3 7LF
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Wednesday, 27 August 2025, 2pm to 3pm
Speakers: Keyon Vafa