Sara-Claudia Anghel
MSc by Research in Oncology
Research Interest:
I am an MSc by Research student investigating T cell dysfunction and immune regulation in cancer. My current research focuses on targeting metabolic checkpoints that drive T cell immunosuppression, with the goal of advancing therapeutic strategies that restore anti-tumour immunity.
Background:
Before joining the University of Oxford, I graduated with First-Class Honours in Biological Sciences (Immunology) with Management from the University of Edinburgh. This interdisciplinary degree reflects my interest in bridging science and business, understanding not only the biological mechanisms of cancer but also how scientific innovation can be translated into healthcare solutions. I conducted my undergraduate dissertation in the Philip Lab, where I addressed the scarcity of effective conditional protein-regulation technologies in the malaria parasite by adapting two novel protein-degradation systems to Plasmodium berghei.
Beyond this, I investigated the genetic foundations of antigen presentation under the supervision of Prof. Jim Kaufman. I have also worked in the laboratory of Prof. Johannes Huppa at the Medical University of Vienna, where I examined TCR–peptide–MHC interactions using lipid bilayer systems and laser microscopy. Prior to this, I contributed to research on the internalisation of pathogenic bacteria in plants at Purdue University in the Deering Lab. In addition to my laboratory work, I designed and implemented a pilot Vetiver-based bio–water sanitation system in Peru, in collaboration with the NGO EcoSwell and Engineering for Change.
Alongside my academic pursuits, I worked on the cancer documentary “Husky Toni - Go Ahead!”, which follows the inspiring story of a cancer survivor. My involvement reflects my passion for connecting science with human stories and public engagement, which has led me to join the committee of the Oxford Society for Science Communication and Engagement.