Contact information
Eileen Parkes
MB BCh, Ba(O) (Hons), MRCP (Onc), PhD
ASSOCIATE PROFESSOR, INNATE TUMOUR IMMUNOLOGY, Group leader
- Consultant Medical Oncologist, Early Phase Trials
RESEARCH SUMMARY
- Understand resistance mechanisms to immune-targeting treatments in cancer;
- Characterise the role of the interaction of chromosomal instability and DNA repair deficiency with immune activation in tumour initiation, progression and response.
- Study tumour microenvironment, fibroblasts and extracellular matrix in chromosomally unstable cancers.
In the Parkes Lab we study intrinsic inflammatory pathways in cancer. These are important immune pathways, present in all cells, that act as emergency response pathways to viral infection. However, in cancer, these pathways can be rewired and hijacked by the tumour to promote growth, invasion and metastasis.
Recent publications
Chromosomal instability shapes the tumor microenvironment of esophageal adenocarcinoma via a cGAS-chemokine-myeloid axis.
Journal article
Beernaert B. et al, (2026), Sci Adv, 12
TMEM33 deletion potentiates anti-tumor CD8+ T cell immunity.
Journal article
Jackson MT. et al, (2026), bioRxiv
Experimental Cancer Medicine Centre (ECMC) network proposal for a consensus gene panel for pan-cancer sequencing: a Delphi methodology.
Journal article
Phillips R. et al, (2026), British journal of cancer, 134, 289 - 294
Single-cell proteomics sheds light on neutrophil diversity in glioblastoma.
Journal article
Skolariki A. and Parkes EE., (2025), Nature reviews. Immunology, 25
IGF-1 regulates cancer cell immune evasion in prostate cancer.
Journal article
Nandakumar AM. et al, (2025), Scientific reports, 15