Publications from the Centre for Immuno-Oncology
Aspirin prevents metastasis by limiting platelet TXA<sub>2</sub> suppression of T cell immunity.
Yang J. et al, (2025), Nature, 640, 1052 - 1061
IFNγ Production by Functionally Reprogrammed Tregs Promotes Antitumor Efficacy of OX40/CD137 Bispecific Agonist Therapy.
Imianowski CJ. et al, (2024), Cancer research communications, 4, 2045 - 2057
Acquisition of suppressive function by conventional T cells limits antitumor immunity upon T<sub>reg</sub> depletion.
Whiteside SK. et al, (2023), Science immunology, 8
BACH2 restricts NK cell maturation and function, limiting immunity to cancer metastasis.
Imianowski CJ. et al, (2022), The Journal of experimental medicine, 219
IL-2 is inactivated by the acidic pH environment of tumors enabling engineering of a pH-selective mutein.
Gaggero S. et al, (2022), Science immunology, 7
CCR8 marks highly suppressive Treg cells within tumours but is dispensable for their accumulation and suppressive function.
Whiteside SK. et al, (2021), Immunology, 163, 512 - 520
A cell-based bioluminescence assay reveals dose-dependent and contextual repression of AP-1-driven gene expression by BACH2.
Vardaka P. et al, (2020), Scientific reports, 10
BACH2 drives quiescence and maintenance of resting Treg cells to promote homeostasis and cancer immunosuppression.
Grant FM. et al, (2020), The Journal of experimental medicine, 217
A distal enhancer at risk locus 11q13.5 promotes suppression of colitis by T<sub>reg</sub> cells.
Nasrallah R. et al, (2020), Nature, 583, 447 - 452
Granzyme B Is an Essential Mediator in CD8<sup>+</sup> T Cell Killing of <i>Theileria parva</i>-Infected Cells.
Yang J. et al, (2019), Infection and immunity, 87, e00386 - e00318
Identification and annotation of bovine granzyme genes reveals a novel granzyme encoded within the trypsin-like locus.
Yang J. et al, (2018), Immunogenetics, 70, 585 - 597
IL-7-dependent maintenance of ILC3s is required for normal entry of lymphocytes into lymph nodes.
Yang J. et al, (2018), The Journal of experimental medicine, 215, 1069 - 1077