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Overall, the time to AIDS after HIV-2 infection is longer than with HIV-1, and many individuals infected with HIV-2 virus remain healthy throughout their lives. Multiple HLA and KIR gene products have been implicated in the control of HIV-1, but the effect of variation at these loci on HIV-2 disease is unknown. We show here for the first time that HLA-B*1503 is associated significantly with poor prognosis after HIV-2 infection and that HLA-B*0801 is associated with susceptibility to infection. Interestingly, previous data indicate that HLA-B*1503 is associated with low viral loads in HIV-1 clade B infection but has no significant effect on viral load in clade C infection. In general, alleles strongly associated with HIV-1 disease showed no effect in HIV-2 disease. These data emphasize the unique nature of the effects of HLA and HLA/KIR combinations on HIV-2 immune responses relative to HIV-1, which could be related to their distinct clinical course.

Original publication

DOI

10.1128/jvi.00116-10

Type

Journal article

Journal

Journal of virology

Publication Date

08/2010

Volume

84

Pages

8202 - 8208

Addresses

Medical Research Council UK, The Gambia.

Keywords

Humans, HIV-2, HIV Infections, Disease Progression, Genetic Predisposition to Disease, Histocompatibility Antigens Class I, HLA-B Antigens, HLA-B8 Antigen, Gene Frequency, Genotype, Polymorphism, Genetic, Adult, Aged, Middle Aged, Ethnic Groups, Africa, Western, Female, Male, Receptors, KIR