Palettes of vaccines and immunostimulatory monoclonal antibodies for combination.
Melero I., Martinez-Forero I., Dubrot J., Suarez N., Palazón A., Chen L.
Various monoclonal antibodies (mAb) target immune system molecules to enhance immunity by costimulating T cells (i.e., CD137, OX40, CD40, GITR) or interfering in coinhibitory signals (i.e., CTLA-4, PD-1). These powerful agents can be guided by cancer vaccines to enhance immunity against tumor but not self tissues. Clinically powerful therapeutic synergies are at hand.