Immunodivergence in Metastatic Colorectal Cancer.
de Andrea CE., Schalper KA., Sanmamed MF., Melero I.
Van den Eynde et al. publish in this issue of Cancer Cell that metastatic colorectal cancer shows marked heterogeneity in T cell infiltration among different lesions and patients. Measurements of T cell infiltration in metastases by immunoscore offer some prognostic information and support immune editing by coevolving adaptive immune responses.