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Cytomegalovirus (CMV) infection is endemic in Gambian infants, with 62% infected by 3 months and 85% by 12 months of age. We studied the CD8 T-cell responses of infants to CMV following primary infection. CMV-specific CD8 T cells, identified with tetramers, showed a fully differentiated phenotype (CD28(-) CD62L(-) CD95(+) perforin(+) granzyme A(+) Bcl-2(low)). Strikingly, the overall CD8 T-cell population developed a similar phenotype following CMV infection, which persisted for at least 12 months. In contrast, primary infection was accompanied by up-regulation of markers of activation (CD45R0 and HLA-D) on both CMV-specific cells and the overall CD8 T-cell population and division (Ki-67) of specific cells, but neither pattern persisted. At 12 months of age, the CD8 T-cell population of CMV-infected infants was more differentiated than that of uninfected infants. Although the subpopulation of CMV-specific cells remained constant, the CMV peptide-specific gamma interferon response was lower in younger infants and increased with age. As the CD8 T-cell phenotype induced by CMV is indicative of immune dysfunction in the elderly, the existence of a similar phenotype in large numbers of Gambian infants raises the question of whether CMV induces a similarly deleterious effect.

Original publication

DOI

10.1128/jvi.00052-07

Type

Journal article

Journal

Journal of virology

Publication Date

06/2007

Volume

81

Pages

5766 - 5776

Addresses

MRC Laboratories Gambia, P.O. Box 273, Banjul, The Gambia. djcm1@liverpool.ac.uk

Keywords

CD8-Positive T-Lymphocytes, Cells, Cultured, Humans, Cytomegalovirus, Cytomegalovirus Infections, Lymphocyte Count, Longitudinal Studies, Cross-Sectional Studies, Immunophenotyping, Lymphocyte Activation, Cell Differentiation, Adult, Infant, Infant, Newborn, Gambia, Female, Male