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HLA-F: A New Kid Licensed for Peptide Presentation.

Sim MJW., Sun PD.

HLA-F, a non-classical MHC molecule, is not known to present peptides. Dulberger et al. (2017) show that HLA-F contains a distinct peptide-binding groove and can present a diverse array of peptides. LIR1, however, recognized HLA-F away from bound peptide, leaving open whether peptide-HLA-F-specific T and NK receptors exist.

More information Original publication

DOI

10.1016/j.immuni.2017.06.004

Type

Journal article

Publication Date

2017-06-01T00:00:00+00:00

Volume

46

Pages

972 - 974

Total pages

2

Addresses

L, a, b, o, r, a, t, o, r, y, , o, f, , I, m, m, u, n, o, g, e, n, e, t, i, c, s, ,, , N, a, t, i, o, n, a, l, , I, n, s, t, i, t, u, t, e, , o, f, , A, l, l, e, r, g, y, , a, n, d, , I, n, f, e, c, t, i, o, u, s, , D, i, s, e, a, s, e, s, ,, , N, I, H, ,, , 1, 2, 4, 4, 1, , P, a, r, k, l, a, w, n, , D, r, i, v, e, ,, , R, o, c, k, v, i, l, l, e, ,, , M, D, , 2, 0, 8, 5, 2, ,, , U, S, A, .

Keywords

Humans, Peptides, Protein Binding