The synthesis and in vivo evaluation of 2',2'-difluoro KRN7000.
Leung L., Tomassi C., Van Beneden K., Decruy T., Trappeniers M., Elewaut D., Gao Y., Elliott T., Al-Shamkhani A., Ottensmeier C., Werner JM., Williams A., Van Calenbergh S., Linclau B.
The synthesis of 2',2'-difluoro KRN7000 is described. In vivo evaluation demonstrates that this fluorinated glycolipid induces CD1d-dependent TCR activation of NKT cells, with a bias towards Th2 cytokine production.