Callum Board
DPhil Student
Research interest:
My research investigates the functional properties of vaccine-induced human antibody responses across diverse disease contexts. Using genetic cloning and protein expression approaches, I reconstruct antibodies from their in vivo–derived sequences through an in-house monoclonal antibody production pipeline. This enables detailed functional characterisation of individual antibodies, including antigen binding, viral neutralisation, and Fc-mediated effector functions, providing insight into immune responses at clonal resolution.
Background:
My previous work has focused on comparing IgG and IgM responses in solid organ transplant recipients following multiple SARS-CoV-2 vaccine doses. Since the recent move of the Barnes Group to the Centre for Immuno-oncology, I aim to extend this framework to examine the functional landscape of vaccine-induced antibodies in the context of preventative cancer vaccines.