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Immune Regulation Laboratory (IRLab) -Galvez-Cancino
Our group aims to understand the immune regulatory mechanisms restricting the activity of effector cells, both lymphoid and myeloid, from attacking the tumour. Using this knowledge, we expect to develop novel antibody and mRNA-based therapeutics.
Tumour-Immune Cell Dynamics - Withers Group
Our research is focused upon understanding how immune cells adapt to, and are changed by tissues, particularly the tumour microenvironment. Deciphering this can resolve the cellular interactions and molecular mechanisms that curtail anti-tumour immunity and need to be targeted to enhance anti-cancer responses.
Secondary and Tertiary Lymphoid Function- Pedroza-Pacheco Group
The overarching goal of the Laboratory for Functional Immunology is to improve our understanding of cellular and molecular mechanisms underlying the regulation of germinal centre responses in vaccination, infection, and cancer, to dissect mechanistic targets that could be used to improve vaccines and therapeutic strategies.
Antigen Processing and Presentation- Elliott Group
My lab has worked on Major histocompatibility complex class I (MHC I) biology for over 35years. MHC I molecules protect us from infections and from cancer by binding to peptides and presenting them to receptors on the surface of cytotoxic T cells or Natural Killer cells. Recognition of peptide-MHC complexes by these receptors activate the cytotoxic cells, leading to the elimination of the cells on which the peptide-MHC complexes are expressed.
Immune Competence in Chronic Diseases- Rowland-Jones Group
Studying Immune Control of HIV-1 and HIV-2 infections: Innate interactions, T cell responses, Osteoimmunology, Drug resistance and Aging.
Innate Sensing in the Tumour Microenvironment and Clinical Trials- Parkes Group
Investigating Inflammatory Pathways in Cancer
Rational Vaccine Development- Borrow Group
Our research seeks to inform the rational design of effective prophylactic and therapeutic approaches to combat HIV-1 infection and target blood cancers; and to understand basic principles of immune function and regulation that have broad application to development of vaccines and therapeutic strategies for infections, tumours and autoimmune disorders.