Molero-Glez P., Azpilikueta A., Mosteo L., Glez-Vaz J., Palencia B., Melero I.

CD137 (4-1BB) costimulation results in the potent activation of antitumor T lymphocytes and elicits antitumor efficacy that is synergistic with anti-PD(L)1 checkpoint inhibitors, especially when using bispecific constructs. Emerging experimental evidence indicates that 4-1BB ligation prevents and may revert T-cell exhaustion. See related article by Jeon et al., p. XX.

CD137 (4-1BB) and T-Lymphocyte Exhaustion.

Molero-Glez P., Azpilikueta A., Mosteo L., Glez-Vaz J., Palencia B., Melero I.

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