Vaccination for Pancreatic Ductal Adenocarcinoma: A Hard Nut to Crack.
Salas-Benito D., Melero I., Ponz-Sarvise M.
No immunotherapy strategy is yet offering consistent results against pancreatic ductal adenocarcinoma. A randomized clinical trial testing repeated immunization with a Listeria monocytogenes-based vaccine encoding for mesothelin in combination with a GM-CSF-transfected allogeneic pancreatic cell vaccine reports no survival benefit for the vaccinated patients.See related article by Le et al., p. 5493.