Double-Stranded RNA to Mimic Viral Infection for Cancer Immunotherapy.
Martínez-Riaño A., Mosteo L., Molero-Glez P., Márquez-Rodas I., Melero I.
The presence of moieties denoting viral infection is crucial to mount powerful cytotoxic T-cell immune responses acting through innate receptors such as Toll-like receptor 3. For cancer immunotherapy, several safe analogues of viral double-stranded RNA are under clinical development following compelling evidence for efficacy in mouse models. See related article by van Eijck et al., p. 3447.