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Rhenium(i) complexes of N-heterocyclic carbene ligands that bind to amyloid plaques of Alzheimer's disease.

Chan CY., Noor A., Noor A., McLean CA., Donnelly PS., Barnard PJ.

A series of [Re(i)L(CO)3]+ complexes (where L is a bifunctional bis(NHC)-amine ligand) that are analogues of potential Tc-99m diagnostic imaging agents for Alzheimer's disease have been synthesised. One of the complexes bound to amyloid plaques in human frontal cortex brain tissue from subjects with Alzheimer's disease.

More information Original publication

DOI

10.1039/c6cc10066j

Type

Journal article

Publication Date

2017-02-01T00:00:00+00:00

Volume

53

Pages

2311 - 2314

Total pages

3

Addresses

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Keywords

Frontal Lobe, Humans, Alzheimer Disease, Rhenium, Methane, Ligands, Microscopy, Fluorescence, Models, Molecular, Coordination Complexes, Plaque, Amyloid, Optical Imaging