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Waywen Loh

MSc Student

Background

I am a graduate student currently studying for an MSc in Integrated Immunology and am now working with Prof. Persephone Borrow at the Centre of Immuno-Oncology. I completed my BSc (Hons) Medical Sciences, graduating with First Class Honours from the University of Edinburgh in 2022, where I have finished a dissertation on investigating the role of NADPH oxidase in neutrophil chemotaxis with Dr. Sonja Vermeren. Besides research, I am also passionate about science communication. I currently work as a subeditor and writer for the Oxford Scientist and I run a science podcast called Research Insider on Spotify. I am originally from Penang, Malaysia. 

Research Interests

Ever since the SARS-CoV-2 pandemic and the rollout of vaccines from Pfizer/BioNTech and Moderna, mRNA vaccines have received renewed interest due to their ease of manufacture and the robust protective immunity generated. However, we currently know very little about these vaccine platforms, particularly how they are detected by the innate immune system, which eventually leads to the generation of a robust humoral and antibody response. My research interest lies in the lipid nanoparticles (LNP) employed to deliver these mRNA vaccines, looking at their effect on the innate immune sensing and their adjuvant effects. My project aims to profile the immune responses elicited from various LNP formulations and better characterise them in order to further optimise the vaccine platform and perhaps dissect the occurrence of adverse events from these vaccines.