NK cells are a subset of innate lymphoid cells originally identified in mice and humans based on their ability to mediate cytotoxicity against transformed cells. However, two recent back-to-back studies in this issue of Cancer Discovery reveal that NK cell infiltration is not always beneficial; rather, it can impair the efficacy of immune checkpoint blockade through immune-regulatory mechanisms. See related article by Pozniak et al., p. 1819 See related article by Song et al., p. 1835.
Journal article
2025-09-01T00:00:00+00:00
15
1777 - 1779
2
Laboratory of Immune-Regulation, Centre for Immuno-Oncology, Nuffield Department of Medicine, Oxford, United Kingdom.
Killer Cells, Natural, Animals, Humans, Mice, Neoplasms, Immunotherapy, Immune Checkpoint Inhibitors