Aviremia 10 Years Postdiscontinuation of Antiretroviral Therapy Initiated During Primary Human Immunodeficiency Virus-1 Infection and Association With Gag-Specific T-Cell Responses.

Kinloch-de Loes S., Dorrell L., Yang H., Hardy GAD., Yerly S., Cellerai C., Vandekerckhove L., De Spielgelaere W., Malatinkova E., Wee Lee Koh W., Johnson MA.

Combination antiretroviral therapy during primary human immunodeficiency virus-1 infection may enable long-term drug-free virological control in rare individuals. We describe a female who maintained aviremia and a normal CD4(+)/CD8(+) T cell ratio for 10 years after stopping therapy, despite a persistent viral reservoir. Cellular immune responses may have contributed to this outcome.

DOI

10.1093/ofid/ofv144

Type

Journal article

Publication Date

2015-12-01T00:00:00+00:00

Volume

2

Addresses

Division of Infection and Immunity , Royal Free Campus, University College London ; Royal Free Hospital , London ; Department of Immunology , University College London Medical School , Royal Free Campus.

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