A series of [Re(i)L(CO)3]+ complexes (where L is a bifunctional bis(NHC)-amine ligand) that are analogues of potential Tc-99m diagnostic imaging agents for Alzheimer's disease have been synthesised. One of the complexes bound to amyloid plaques in human frontal cortex brain tissue from subjects with Alzheimer's disease.
Journal article
2017-02-01T00:00:00+00:00
53
2311 - 2314
3
Department of Chemistry and Physics, La Trobe Institute for Molecular Science, La Trobe University, Victoria 3086, Australia. p.barnard@latrobe.edu.au.
Frontal Lobe, Humans, Alzheimer Disease, Rhenium, Methane, Ligands, Microscopy, Fluorescence, Models, Molecular, Coordination Complexes, Plaque, Amyloid, Optical Imaging